Reciprocal Detoxifying Effects of ‘Benadryl’ and ‘Aminopterin’

Abstract

AN attempt has been made to overcome the toxic effect of the 4-aminopteroylglutamic acid, the new powerful folic acid antagonist1. Aminopterin is toxic to all laboratory animals used and also to human beings2–7. Its toxic effects are difficult to prevent or to reverse by administration of folic acid6–10, whereas the effects of theX-methyl analogues of folic… (More)
DOI: 10.1038/166158a0

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