Recipient of the 2011 Molecular Ecology Prize: Deborah Charlesworth

  title={Recipient of the 2011 Molecular Ecology Prize: Deborah Charlesworth},
  author={Stephen J Wright},
  journal={Molecular Ecology},
Deborah Charlesworth (photo credit: Spencer Barrett) For the past 35 years, Professor Deborah Charlesworth (University of Edinburgh) has been a pioneer in the fields of evolutionary genetics, plant population genetics and the evolution of plant sexual systems. She has made seminal contributions to our understanding of the evolutionary importance of recombination and inbreeding depression, and the evolution of sex chromosomes in plants. By tightly linking theoretical population genetics with… Expand
Deborah Charlesworth, winner of the society for the study of evolution's inaugural lifetime achievement award: Evolutionary biology for the genomics era
  • S. Wright
  • Biology, Medicine
  • Evolution; international journal of organic evolution
  • 2021
An evolutionary genetics perspective is key for understanding the burgeoning amounts of genomic data, and genomics is opening up exciting new questions and opportunities to address and parameterize evolutionary models. Expand


The evidence that the evolution of breeding systems of animals and plants has been significantly influenced by the occurrence of inbreeding depression is reviewed, and the contemporary genetic theory of inmarriage depression and heterosis and the experimental data concerning the strength of in breeding depression are considered. Expand
Reduced Efficacy of Natural Selection on Codon Usage Bias in Selfing Arabidopsis and Capsella Species
Evidence is found that selection on synonymous codons is significantly weaker in the selfers compared with the outcrossers and that this difference cannot be fully accounted for by mutational biases or BGC. Expand
Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry
The results indicate that allelic combinations at known wing-patterning loci have become locked together in a polymorphic rearrangement at the P locus, forming a supergene that acts as a simple switch between complex adaptive phenotypes found in sympatry. Expand
Low variability in a Y-linked plant gene and its implications for Y-chromosome evolution
DNA polymorphism in SLY-1 is 20-fold lower than in SLX-1, but the pattern of polymorphism does not suggest a selective sweep, and these processes lower effective population sizes, and therefore reduce variability of genes in evolving Y chromosomes. Expand
Evolutionary Strata on the X Chromosomes of the Dioecious Plant Silene latifolia: Evidence From New Sex-Linked Genes
It is concluded that the divergence value is saturated, confirming the cessation of X–Y recombination in the evolution of the sex chromosomes at ∼10–20 MYA. Expand
Evidence for Degeneration of the Y Chromosome in the Dioecious Plant Silene latifolia
Testing whether the S. latifolia Y chromosome is undergoing genetic degeneration by analyzing seven sex-linked genes detects signs of degeneration in most of the Y- linked gene sequences analyzed, similar to those of animal Y-linked and neo-Y chromosome genes. Expand
Preservation of the Y Transcriptome in a 10-Million-Year-Old Plant Sex Chromosome System
This approach identifies several hundred new sex-linked genes, and it is shown that this young Y chromosome retains many genes, yet these already have slightly reduced gene expression and are accumulating changes likely to reduce protein functions. Expand
An X-linked gene with a degenerate Y-linked homologue in a dioecious plant
It is shown that a gene encoding a male-specific protein is linked to the X chromosome in the dioecious plant Silene latifolia, and that it has a degenerate homologue in the non-pairing region of the Y chromosome. Expand
The effect of mating system differences on nucleotide diversity at the phosphoglucose isomerase locus in the plant genus Leavenworthia.
To test the theoretical prediction that highly inbreeding populations should have low neutral genetic diversity relative to closely related outcrossing populations, we sequenced portions of theExpand
A Model for the Evolution of Distyly
It is shown by computer runs that modifiers causing tighter linkage will spread in populations with two incompatibility types, and species in which the more self-compatible form is recessive cannot be explained by this model, but can be accounted for if the gene affecting the stigma reaction also controls its position. Expand