Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury.

@article{Liu2015RecipientTC,
  title={Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury.},
  author={Yuanxing Liu and Haofeng Ji and Yu Zhang and Xiuda Shen and Feng Gao and Xiangyi He and Gabriella A Li and Ronald W Busuttil and Vijay K Kuchroo and Jerzy W. Kupiec-Weglinski},
  journal={Journal of hepatology},
  year={2015},
  volume={62 3},
  pages={
          563-72
        }
}

• Yuanxing Liu, Haofeng Ji, +7 authors Jerzy W. Kupiec-Weglinski
• Published 2015 in Journal of hepatology
• DOI:10.1016/j.jhep.2014.10.034

BACKGROUND & AIMS By binding to T cell immunoglobulin mucin-3 (TIM-3) on activated Th1 cells, galectin-9 (Gal-9) negatively regulates Th1-type alloimmunity. Although T cells contribute to hepatic ischemia-reperfusion injury (IRI), it is unknown whether negative T cell-dependent TIM-3 co-stimulation may rescue IR-stressed orthotopic liver transplants from innate immunity-driven inflammation. METHODS We used wild type (WT) and TIM-3 transgenic (Tg) mice (C57BL/6) as liver donors and recipients… CONTINUE READING

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