• Corpus ID: 45537853

Recharge With Pregnenolone

  title={Recharge With Pregnenolone},
  author={Dave Tuttle},
An Essential Hormone Testosterone, estrogen, cortisol, DHEA, and pregnenolone are members of a family of natural hormones that are essential for human survival. All of these hormones contain four carbon-ring structures attached to each other, and appear very similar.1Small differences in structure, however, produce dramatic changes in function. Testosterone, the “male” hormone, is only slightly different chemically from estrogen, the “female” hormone. Yet this minor dissimilarity causes men to… 


Sex- and age-related changes in epitestosterone in relation to pregnenolone sulfate and testosterone in normal subjects.
Concentrations of epitestosterone and pregnenolone sulfate are age dependent and, at least in prepubertal boys and girls, epitest testosterone reaches or even exceeds the concentrations of T, thus supporting its role as an endogenous antiandrogen.
Pregnenolone Sulfate and Aging of Cognitive Functions: Behavioral, Neurochemical, and Morphological Investigations
Data suggest that PREG-S can influence cognitive processes, particularly in senescent subjects, through a modulation of ACh neurotransmission associated with paradoxical sleep modifications; furthermore the recent data suggest a role for neurosteroids in the modulation of hippocampal neurogenesis.
Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus.
  • M. Vallée, W. Mayo, H. Simon
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
It is proposed that the hippocampal content of PREG S plays a physiological role in preserving and/or enhancing cognitive abilities in old animals, possibly via an interaction with central cholinergic systems.
Low pregnenolone sulphate plasma concentrations in patients with generalized social phobia
Results are particularly interesting since lower pregnenolone sulphate concentrations in male patients suffering from generalized anxiety disorder are observed, since these results areparticularly interesting since they are observed in patients with generalized social phobia.
GABA—The quintessential neurotransmitter: Electroneutrality, fidelity, specificity, and a model for the ligand binding site of GABAA receptors
The above, together with diminution upon acidification of the postsynaptic efficacy of glutamate on excitatory NMDA receptors constitutes a sensitively responsive mechanism by which protons control levels of neural activity, locally and globally.