Rechallenge with lamotrigine after a rash: a prospective case series and review of the literature.

@article{Aiken2010RechallengeWL,
  title={Rechallenge with lamotrigine after a rash: a prospective case series and review of the literature.},
  author={Chris B Aiken and Carolyn F. Orr},
  journal={Psychiatry (Edgmont (Pa. : Township))},
  year={2010},
  volume={7 5},
  pages={27-32}
}
OBJECTIVE To investigate the safety of rechallenge with lamotrigine after an initial rash in patients with refractory bipolar depression. DESIGN 1) Prospective, open-label case series in a private practice setting. Patients who developed an initial rash on lamotrigine and were refractory to other treatments were offered rechallenge with the drug using very-low-dose titration (5mg every other day or daily for 14 days, then raised every 14 days by daily-dose increments of 5mg; after 25mg/day… CONTINUE READING
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