Receptors with V1 characteristics mediate the maintenance of ethanol tolerance by vasopressin.

@article{Szab1988ReceptorsWV,
  title={Receptors with V1 characteristics mediate the maintenance of ethanol tolerance by vasopressin.},
  author={G{\'a}bor Szab{\'o} and Boris Tabakoff and Paula L. Hoffman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1988},
  volume={247 2},
  pages={536-41}
}
The neurohypophyseal hormone arginine vasopressin (AVP) acts in the central nervous system (CNS) to maintain functional tolerance to several effects of ethanol. The ability of exogenous vasopressin (administered i.c.v.) to maintain tolerance to the hypnotic effect of ethanol was blocked more effectively by antagonists acting at V1 receptors than by a V2-selective antagonist. Similarly, a V1-selective agonist was more potent than AVP in maintaining tolerance, whereas V2-selective agonists were… CONTINUE READING