Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status.

@article{Pamir2009ReceptorsFT,
  title={Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status.},
  author={Nathalie Pamir and Timothy S. McMillen and Karl J Kaiyala and Michael J. Schwartz and Ren{\'e}e C Leboeuf},
  journal={Endocrinology},
  year={2009},
  volume={150 9},
  pages={4124-34}
}
TNF-alpha signals through two receptors, TNFR1 and TNFR2. Our goals were: 1) determine the role of TNFRs in obesity and metabolic disease and 2) investigate whether TNFRs contribute to the link between obesity and adipose tissue macrophage infiltration and polarization. R1(-/-)R2(-/-) (RKO) and wild-type (WT) mice were fed standard chow or a high-fat/high-sucrose diet (HFHS) over 14 wk. Body composition, food intake, and energy expenditure were measured. Oral glucose tolerance and insulin… CONTINUE READING
28 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…