Receptors for platelet-derived growth factor on microvascular endothelial cells.

@article{Beitz1992ReceptorsFP,
  title={Receptors for platelet-derived growth factor on microvascular endothelial cells.},
  author={Julie G Beitz and Ik Soo Kim and Paul Calabresi and A. Raymond Frackelton},
  journal={EXS},
  year={1992},
  volume={61},
  pages={85-90}
}
Endothelial cells are widely thought to be unresponsive to platelet-derived growth factor (PDGF) and devoid of PDGF receptors. However, in examining the growth factor responses of microvascular endothelial cells isolated from human omental adipose tissue, we detected PDGF-induced tyrosine phosphorylation of an 180-kD glycoprotein, subsequently identified as the cellular receptor for PDGF by specific immunoprecipitation. Scatchard analysis of 125I-PDGF binding to human microvascular endothelial… CONTINUE READING