Receptors for insulin-like growth factors-I and -II in osteoblast-enriched cultures from fetal rat bone.

@article{Centrella1990ReceptorsFI,
  title={Receptors for insulin-like growth factors-I and -II in osteoblast-enriched cultures from fetal rat bone.},
  author={Michael Centrella and Thomas L. McCarthy and Ernesto Canalis},
  journal={Endocrinology},
  year={1990},
  volume={126 1},
  pages={39-44}
}
Insulin-like growth factors-I and -II (IGF-I and IGF-II) are produced by bone cells and stored in bone matrix, and stimulate bone cell DNA synthesis and type I collagen production. Earlier studies in cells from an assortment of tissues indicate that IGF-I binds to membrane receptors of various relative molecular mass (Mr), whereas IGF-II binds predominantly to the mannose-6-phosphate transferase. In the present studies we have examined the IGF receptor profile in osteoblast-enriched cultures… CONTINUE READING

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