Receptors for epidermal growth factor and insulin-like growth factor-I on preimplantation trophoderm of the pig.

@article{Corps1990ReceptorsFE,
  title={Receptors for epidermal growth factor and insulin-like growth factor-I on preimplantation trophoderm of the pig.},
  author={Anthony N. Corps and David R Brigstock and Chris Littlewood and K D Brown},
  journal={Development},
  year={1990},
  volume={110 1},
  pages={221-7}
}
125I-labelled epidermal growth factor (125I-EGF) and 125I-labelled insulin-like growth factor-I (125I-IGF-I) bound to trophoderm cells from pig blastocysts obtained on days 15-19 of pregnancy. Specific binding was detected on freshly isolated cell suspensions and on cells cultured for several days. The binding of 125I-EGF was inhibited by increasing concentrations of EGF, but not by various other growth factors and hormones. Chemical cross-linking of 125I-EGF to its receptors using… CONTINUE READING