Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2.

@article{Lee2008ReceptorsFC,
  title={Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2.},
  author={Hyun Seung Lee and Peter L Whitfeld and Charles R Mackay},
  journal={Immunology and cell biology},
  year={2008},
  volume={86 2},
  pages={
          153-60
        }
}
Complement component C5a is one of the most potent inflammatory chemoattractants and has been implicated in the pathogenesis of numerous inflammatory diseases. C5a binds two receptors, C5aR and C5L2. Most of the C5a functional effects occur through C5aR, and the pharmaceutical industry has focused on this receptor for the development of new anti-inflammatory therapies. We used a novel approach to generate and test therapeutics that target C5aR. We created human C5aR knock-in mice, and used… CONTINUE READING
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