Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.

@article{Grel2012ReceptorsAO,
  title={Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.},
  author={G{\"u}liz G{\"u}rel and Megan A Gustafson and J. S. Pepper and H Robert Horvitz and Michael R Koelle},
  journal={Genetics},
  year={2012},
  volume={192 4},
  pages={1359-71}
}
A better understanding of the molecular mechanisms of signaling by the neurotransmitter serotonin is required to assess the hypothesis that defects in serotonin signaling underlie depression in humans. Caenorhabditis elegans uses serotonin as a neurotransmitter to regulate locomotion, providing a genetic system to analyze serotonin signaling. From large-scale genetic screens we identified 36 mutants of C. elegans in which serotonin fails to have its normal effect of slowing locomotion, and we… CONTINUE READING
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