Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104.

@article{Brando2005ReceptorsAL,
  title={Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104.},
  author={Clara Brando and Sunil Mukhopadhyay and Enikő Kov{\'a}cs and Rosa M. Medina and Pritesh Patel and Tracey L. Catina and Kerry S. Campbell and Daniela Santoli},
  journal={Journal of leukocyte biology},
  year={2005},
  volume={78 2},
  pages={359-71}
}
The major histocompatibility complex nonrestricted cytotoxic leukemic T cell line T acute lymphoblastic leukemia (TALL)-104 is being pursued as a therapeutic agent for cancer. However, the receptors and effector mechanisms responsible for its broad tumoricidal function remain undefined. Here, we examined the roles played by natural cytotoxicity receptors (NCR), killer cell immunoglobulin-like receptors, cytolytic granule components, and tumor necrosis factor (TNF) family members in tumor… CONTINUE READING