Receptors and lytic mediators regulating anti‐tumor activity by the leukemic killer T cell line TALL‐104

  title={Receptors and lytic mediators regulating anti‐tumor activity by the leukemic killer T cell line TALL‐104},
  author={C. Brando and S. Mukhopadhyay and E. Kov{\'a}cs and Rosa Medina and P. Patel and Tracey L. Catina and K. Campbell and D. Santoli},
  journal={Journal of Leukocyte Biology},
  • C. Brando, S. Mukhopadhyay, +5 authors D. Santoli
  • Published 2005
  • Biology, Medicine
  • Journal of Leukocyte Biology
  • The major histocompatibility complex nonrestricted cytotoxic leukemic T cell line T acute lymphoblastic leukemia (TALL)‐104 is being pursued as a therapeutic agent for cancer. However, the receptors and effector mechanisms responsible for its broad tumoricidal function remain undefined. Here, we examined the roles played by natural cytotoxicity receptors (NCR), killer cell immunoglobulin‐like receptors, cytolytic granule components, and tumor necrosis factor (TNF) family members in tumor… CONTINUE READING
    20 Citations
    NKG2D Initiates Caspase-Mediated CD3ζ Degradation and Lymphocyte Receptor Impairments Associated with Human Cancer and Autoimmune Disease
    • 38
    • PDF
    NKG2A inhibits TH2 cell effector function in vitro
    • 1
    Roles for TRAIL in the immune response to influenza virus infection
    CD8 T Cells Utilize TRAIL to Control Influenza Virus Infection1
    • 139
    • PDF
    Functional Polymorphisms of FAS and FASL Gene and Risk of Breast Cancer – Pilot Study of 134 Cases
    • 71
    • PDF


    Two unique human leukemic T-cell lines endowed with a stable cytotoxic function and a different spectrum of target reactivity analysis and modulation of their lytic mechanisms
    • 29
    Tumor necrosis factor receptor and Fas signaling mechanisms.
    • 1,356
    Cellular and molecular mechanisms of activation of MHC nonrestricted cytotoxic cells by IL-12.
    • 95
    Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.
    • 1,756
    Tumor necrosis factor receptor-mediated signaling pathways
    • 379
    • PDF