Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets

@article{Ribeiro2016ReceptorUD,
  title={Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets},
  author={Carla Ms Ribeiro and Ramin Sarrami-Forooshani and L. Christiana Setiawan and Esther M. Zijlstra-Willems and John L. van Hamme and Wikky Tigchelaar and Nicole van der Wel and Neeltje A Kootstra and Sonja Inge Gringhuis and Teunis Bh Geijtenbeek},
  journal={Nature},
  year={2016},
  volume={540},
  pages={448-452}
}
The most prevalent route of HIV-1 infection is across mucosal tissues after sexual contact. Langerhans cells (LCs) belong to the subset of dendritic cells (DCs) that line the mucosal epithelia of vagina and foreskin and have the ability to sense and induce immunity to invading pathogens. Anatomical and functional characteristics make LCs one of the primary targets of HIV-1 infection. Notably, LCs form a protective barrier against HIV-1 infection and transmission. LCs restrict HIV-1 infection… CONTINUE READING
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