Receptor uptake arrays for vitamin B12, siderophores, and glycans shape bacterial communities

@article{Frank2017ReceptorUA,
  title={Receptor uptake arrays for vitamin B12, siderophores, and glycans shape bacterial communities},
  author={Steven A. Frank},
  journal={Ecology and Evolution},
  year={2017},
  volume={7},
  pages={10175 - 10195}
}
  • S. Frank
  • Published 1 June 2017
  • Biology
  • Ecology and Evolution
Abstract Molecular variants of vitamin B12, siderophores, and glycans occur. To take up variant forms, bacteria may express an array of receptors. The gut microbe Bacteroides thetaiotaomicron has three different receptors to take up variants of vitamin B12 and 88 receptors to take up various glycans. The design of receptor arrays reflects key processes that shape cellular evolution. Competition may focus each species on a subset of the available nutrient diversity. Some gut bacteria can take up… 
3 Citations
Functional Roles of B-Vitamins in the Gut and Gut Microbiome.
TLDR
The function of single B-vitamin in the distal gut including their roles in relation to bacteria is reviewed and the prospect of extending analytical methods to better understand the role of B- vitamins in the gut is explored.
Selective colonization ability of human fecal microbes in different mouse gut environments
TLDR
It is found that mouse genotypes and the native mouse gut microbiota both exerted different selective pressures on exogenous colonizers: human fecal Bacteroides successfully established in the mice gut, however, different species of Bactroides selectively enriched under different gut conditions, potentially due to a multitude of functional differences.

References

SHOWING 1-10 OF 123 REFERENCES
Dynamic responses of Bacteroides thetaiotaomicron during growth on glycan mixtures
TLDR
Insight is provided into how a bacterial glycan generalist modifies its responses in dynamic glycan environments and essential knowledge is provided to interpret related metabolic behaviour in vivo.
Symbiotic Human Gut Bacteria with Variable Metabolic Priorities for Host Mucosal Glycans
TLDR
Investigating the responses of Bacteroides thetaiotaomicron, a common human intestinal bacterium that metabolizes more than a dozen different polysaccharides, reveals new aspects of how individual bacteria partition to “preferred niches” in the complex gut ecosystem, which has important and immediate implications for understanding and predicting the behavioral dynamics of this community.
A survey of TonB-dependent receptors in fluorescent pseudomonads.
TLDR
This study strongly supports the notion of 'core' and 'accessory' TonB-dependent receptors within each species, with the ferripyoverdine receptors belonging to the last category.
Polysaccharide Utilization Loci: Fueling Microbial Communities.
TLDR
This review provides historical perspectives and summarizes key findings in the study of Bacteroidetes bacteria, highlighting a critical shift from sequence-based PUL discovery to systems-based analyses combining reverse genetics, biochemistry, enzymology, and structural biology to precisely illuminate the molecular mechanisms underpinning PUL function.
Structural basis for nutrient acquisition by dominant members of the human gut microbiota
TLDR
X-ray crystal structures of two functionally distinct SusCD complexes purified from Bacteroides thetaiotaomicron are presented and a general model for substrate translocation is derived to provide mechanistic insights into outer membrane nutrient import by members of the microbiota, an area of major importance for understanding human–microbiota symbiosis.
A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism.
TLDR
Yeast two-hybrid screens revealed that the cytoplasmic portion of BT3172's sensor domain serves as a scaffold for recruiting glucose-6-phosphate isomerase and dehydrogenase, and this HTCS functions as a metabolic reaction center, coupling nutrient sensing to dynamic regulation of monosaccharide metabolism.
Diversity of siderophore-mediated iron uptake systems in fluorescent pseudomonads: not only pyoverdines.
TLDR
A first genomic analysis of receptors in four different fluorescent pseudomonads suggests that their siderophore ligand repertoire is likely to overlap, and that not all receptors recognize siderophile ligands as ligands.
Molecular Dissection of Xyloglucan Recognition in a Prominent Human Gut Symbiont
TLDR
This work provides the first biochemical, crystallographic, and genetic insight into how two surface glycan-binding proteins from the complex Bacteroides ovatus xyloglucan utilization locus (XyGUL) enable recognition and uptake of this ubiquitous vegetable polysaccharide.
Functional characterization of polysaccharide utilization loci in the marine Bacteroidetes ‘Gramella forsetii' KT0803
TLDR
The decomposition of the algal glycans laminarin and alginate by ‘Gramella forsetii’ KT0803, a bacteroidetal isolate from North Sea surface waters is studied to contribute to an improved understanding of the ecological niches of marine Bacteroidetes and their roles in the polysaccharide decomposition part of carbon cycling in marine ecosystems.
Microbial degradation of complex carbohydrates in the gut
TLDR
The impact of dietary carbohydrates, including prebiotics, on human health requires understanding of the complex relationship between diet composition, the gut microbiota and metabolic outputs.
...
...