Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks.

@article{Wagner2013ReceptorTK,
  title={Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks.},
  author={Joel P. Wagner and Alejandro Wolf-Yadlin and Mark Sevecka and Jennifer K. Grenier and David E Root and Douglas A. Lauffenburger and Gavin Macbeath},
  journal={Science signaling},
  year={2013},
  volume={6 284},
  pages={ra58}
}
Although many anticancer drugs that target receptor tyrosine kinases (RTKs) provide clinical benefit, their long-term use is limited by resistance that is often attributed to increased abundance or activation of another RTK that compensates for the inhibited receptor. To uncover common and unique features in the signaling networks of RTKs, we measured time-dependent signaling in six isogenic cell lines, each expressing a different RTK as downstream proteins were systematically perturbed by RNA… CONTINUE READING
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