Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks.

  title={Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks.},
  author={Joel P. Wagner and Alejandro Wolf-Yadlin and Mark Sevecka and Jennifer K. Grenier and David E Root and Douglas A. Lauffenburger and Gavin Macbeath},
  journal={Science signaling},
  volume={6 284},
Although many anticancer drugs that target receptor tyrosine kinases (RTKs) provide clinical benefit, their long-term use is limited by resistance that is often attributed to increased abundance or activation of another RTK that compensates for the inhibited receptor. To uncover common and unique features in the signaling networks of RTKs, we measured time-dependent signaling in six isogenic cell lines, each expressing a different RTK as downstream proteins were systematically perturbed by RNA… CONTINUE READING
Highly Cited
This paper has 1,839 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 24 times over the past 90 days. VIEW TWEETS
19 Citations
61 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 19 extracted citations

1,840 Citations

Citations per Year
Semantic Scholar estimates that this publication has 1,840 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 61 references

Activation of the AXL kinase causes resistance to EGFRtargeted therapy in lung cancer

  • V. J. Craig, S. Sanghavi, +15 authors R. Tiedt
  • Nat . Genet .
  • 2012

Similar Papers

Loading similar papers…