Receptor tyrosine kinases as targets for anticancer drugs.

  title={Receptor tyrosine kinases as targets for anticancer drugs.},
  author={Esther Zwick and Johannes Bange and Axel Ullrich},
  journal={Trends in molecular medicine},
  volume={8 1},
Receptor tyrosine kinases (RTKs) are the primary mediators of the signaling network that transmit extracellular signals into the cell. Gene amplification and/or overexpression of RTK proteins or functional alterations caused by mutations in the corresponding genes or abnormal autocrine-paracrine growth factor loops contribute to constitutive RTK signaling, ultimately resulting in the manifestation of dysregulated cell growth and cancer. The mechanism of uncontrolled RTK signaling that leads to… CONTINUE READING

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