Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury

  title={Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury},
  author={D. Valenzuela and T. Stitt and P. Distefano and E. Rojas and K. Mattsson and D. Compton and L. Nu{\~n}ez and J. Park and J. L. Stark and David R. Gies and S. Thomas and M. Beau and A. A. Fernald and N. Copeland and N. Jenkins and S. Burden and D. Glass and G. Yancopoulos},
  • D. Valenzuela, T. Stitt, +15 authors G. Yancopoulos
  • Published 1995
  • Biology, Medicine
  • Neuron
  • While a number of growth factors have been described that are highly specific for particular cell lineages, neither a factor nor a receptor uniquely specific to the skeletal muscle lineage has previously been described. Here we identify a receptor tyrosine kinase (RTK) specific to skeletal muscle, which we term "MuSK" for muscle-specific kinase. MuSK is expressed at low levels in proliferating myoblasts and is induced upon differentiation and fusion. In the embryo, it is specifically expressed… CONTINUE READING
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