Receptor tyrosine kinase mutations in developmental syndromes and cancer: two sides of the same coin.

  title={Receptor tyrosine kinase mutations in developmental syndromes and cancer: two sides of the same coin.},
  author={Laura M McDonell and Kristin D. Kernohan and Kym M. Boycott and Sarah L. Sawyer},
  journal={Human molecular genetics},
  volume={24 R1},
Receptor tyrosine kinases (RTKs) are a family of ligand-binding cell surface receptors that regulate a wide range of essential cellular activities, including proliferation, differentiation, cell-cycle progression, survival and apoptosis. As such, these proteins play an important role during development and throughout life; germline mutations in genes encoding RTKs cause several developmental syndromes, while somatic alterations contribute to the pathogenesis of many aggressive cancers. This… 

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