Receptor tyrosine kinase-mediated angiogenesis.

@article{Jeltsch2013ReceptorTK,
  title={Receptor tyrosine kinase-mediated angiogenesis.},
  author={Michael Jeltsch and Veli-Matti Lepp{\"a}nen and Pipsa Saharinen and Kari Alitalo},
  journal={Cold Spring Harbor perspectives in biology},
  year={2013},
  volume={5 9}
}
The endothelial cell is the essential cell type forming the inner layer of the vasculature. Two families of receptor tyrosine kinases (RTKs) are almost completely endothelial cell specific: the vascular endothelial growth factor (VEGF) receptors (VEGFR1-3) and the Tie receptors (Tie1 and Tie2). Both are key players governing the generation of blood and lymphatic vessels during embryonic development. Because the growth of new blood and lymphatic vessels (or the lack thereof) is a central element… CONTINUE READING

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