Receptor tyrosine kinase expression in astrocytic lesions: similar features in gliosis and glioma.

@article{Kristt1993ReceptorTK,
  title={Receptor tyrosine kinase expression in astrocytic lesions: similar features in gliosis and glioma.},
  author={Donald A. Kristt and E K Reedy and Yossi Yarden},
  journal={Neurosurgery},
  year={1993},
  volume={33 1},
  pages={106-15}
}
The purpose of this study was to determine if the expression of receptor tyrosine kinases would distinguish astrocytosis from astrocytoma. Because the expression of this family of receptor proteins is greater in higher-grade tumors, a graded series of both reactive and neoplastic astrocytic lesions in humans was evaluated. The reactive processes included both mild gliosis and severe (intense) gliosis. The two immunocytochemically detected membrane receptor proteins, p145 and p185, are those… CONTINUE READING
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