Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

@article{Blesen1995ReceptortyrosinekinaseAG,
  title={Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway},
  author={Tim van Blesen and Brian E. Hawes and Deirdre K. Luttrell and Kathleen M. Krueger and Kazushige Touhara and Emilio Porfflri and Motoyoshi Sakaue and Louis M. Luttrell and Robert J Lefkowitz},
  journal={Nature},
  year={1995},
  volume={376},
  pages={781-784}
}
MITOGEN-ACTIVATED protein (MAP) kinases mediate the phos-phorylation and activation of nuclear transcription factors that regulate cell growth1. MAP kinase activation may result from stimulation of either tyrosine-kinase (RTK) receptors, which possess intrinsic tyrosine kinase activity, or G-protein-coupIed receptors (GPCR)2–4. RTK-mediated mitogenic signalling involves a series of SH2- and SH3-dependent protein-protein interactions between tyrosine-phosphorylated receptor, She, Grb2 and Sos… CONTINUE READING