Receptor tyrosine kinase amplified gastric cancer: Clinicopathologic characteristics and proposed screening algorithm

@inproceedings{Park2016ReceptorTK,
  title={Receptor tyrosine kinase amplified gastric cancer: Clinicopathologic characteristics and proposed screening algorithm},
  author={Cheol Keun Park and Ji Soo Park and Hyo Song Kim and Sun Young Rha and Woo Jin Hyung and Jae-Ho Cheong and Sung Hoon Noh and Sang Kil Lee and Yong Chan Lee and Yong-Min Huh and Hyunki Kim},
  booktitle={Oncotarget},
  year={2016}
}
Although targeted therapy for receptor tyrosine kinases (RTKs) of advanced gastric cancers (AGCs) has been in the spotlight, guidelines for the identification of RTK-amplified gastric cancers (RA-GCs) have not been established. In this study, we investigate clinicopathologic characteristics of RA-GCs and propose a screening algorithm for their identification. We performed immunohistochemistry (IHC) for MLH1, MSH2, PMS2, MSH6, key RTKs (EGFR, HER2, MET), and p53, in situ hybridization for… CONTINUE READING