Receptor tyrosine kinase-GPCR signal complexes.

  title={Receptor tyrosine kinase-GPCR signal complexes.},
  author={Nigel J. Pyne and Catherine Waters and Noreen Akhtar Moughal and Balwinder S Sambi and Susan Pyne},
  journal={Biochemical Society transactions},
  volume={31 Pt 6},
The formation of complexes between growth factor receptors and members of a family of G-protein-coupled receptors whose natural ligands are S1P (sphingosine 1-phosphate) and LPA (lysophosphatidic acid) represents a new signalling entity. This receptor complex allows for integrated signalling in response to growth factor and/or S1P/LPA and provides a mechanism for more efficient activation (due to integrated close-proximity signalling from both receptor classes) of the p42/p44 MAPK (mitogen… CONTINUE READING