Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34.

  title={Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34.},
  author={Sayan Nandi and Mario Cioce and Y G Yeung and Edward Nieves and Lydia Tesfa and Haishan Lin and Amy W Hsu and Robert Halenbeck and H. Cheng and Solen Gokhan and Mark F. Mehler and E Richard Stanley},
  journal={The Journal of biological chemistry},
  volume={288 30},
Interleukin-34 (IL-34) is highly expressed in brain. IL-34 signaling via its cognate receptor, colony-stimulating factor-1 receptor (CSF-1R), is required for the development of microglia. However, the differential expression of IL-34 and the CSF-1R in brain suggests that IL-34 may signal via an alternate receptor. By IL-34 affinity chromatography of solubilized mouse brain membrane followed by mass spectrometric analysis, we identified receptor-type protein-tyrosine phosphatase ζ (PTP-ζ), a… CONTINUE READING
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