Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps.

@article{Wu2012ReceptortransportingP1,
  title={Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps.},
  author={Lifang Wu and Yi Pan and G Chen and Hiroaki Matsunami and Hanyi Zhuang},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 26},
  pages={22287-94}
}
Odorant receptor (OR) proteins are retained in the endoplasmic reticulum when heterologously expressed in cultured cells of non-olfactory origins. RTP1S is an accessory protein to mammalian ORs and facilitates their trafficking to the cell-surface membrane and ligand-induced responses in heterologous cells. The mechanism by which RTP1S promotes the functional expression of ORs remains poorly understood. To obtain a better understanding of the role(s) of RTP1S, we performed a series of structure… CONTINUE READING