Receptor-transporting Protein 1 Short (RTP1S) Mediates Translocation and Activation of Odorant Receptors by Acting through Multiple Steps*

@article{Wu2012ReceptortransportingP1,
  title={Receptor-transporting Protein 1 Short (RTP1S) Mediates Translocation and Activation of Odorant Receptors by Acting through Multiple Steps*},
  author={L. Wu and Yi Pan and Guo-Qiang Chen and H. Matsunami and Hanyi Zhuang},
  journal={The Journal of Biological Chemistry},
  year={2012},
  volume={287},
  pages={22287 - 22294}
}
  • L. Wu, Yi Pan, +2 authors Hanyi Zhuang
  • Published 2012
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • Background: RTP1S facilitates the translocation of odorant receptors (ORs). Results: Different domains in RTP1S are important for different stages of OR trafficking, odorant-mediated responses, and interaction with ORs. Conclusion: RTP1S mediates the trafficking and ligand-induced response of ORs by acting through multiple steps. Significance: Probing the structure-function of RTP1S is crucial for understanding the mechanism of OR trafficking and activation. Odorant receptor (OR) proteins are… CONTINUE READING

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