Receptor targets for antidepressant therapy in bipolar disorder: an overview.

  title={Receptor targets for antidepressant therapy in bipolar disorder: an overview.},
  author={Konstantinos N Fountoulakis and John Kelsoe and Hagop Souren Akiskal},
  journal={Journal of affective disorders},
  volume={138 3},
The treatment of bipolar depression is one of the most challenging issues in contemporary psychiatry. Currently only quetiapine and the olanzapine-fluoxetine combination are officially approved by the FDA against this condition. The neurobiology of bipolar depression and the possible targets of bipolar antidepressant therapy remain relatively elusive. We performed a complete and systematic review to identify agents with definite positive or negative results concerning efficacy followed by a… CONTINUE READING
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