Receptor-targeted liposome-peptide nanocomplexes for siRNA delivery.

  title={Receptor-targeted liposome-peptide nanocomplexes for siRNA delivery.},
  author={Aristides D. Tagalakis and Lin He and Luisa Saraiva and K Gustafsson and Stephen L Hart},
  volume={32 26},
RNA interference induced by double-stranded, small interfering RNA (siRNA) molecules has attracted great attention as a genetic therapeutic approach. Despite major advances in this field, new nanoparticle formulations are required for in vivo delivery of siRNA, particularly for tissue-specific delivery of siRNA reagents. We have developed and optimized LYR nanocomplex formulations for siRNA delivery that consist of a liposome (DOTMA/DOPE; L) and a targeting peptide (K₁₆GACYGLPHKFCG; Y) which… CONTINUE READING
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