Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.

@article{Liu2001ReceptorSP,
  title={Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors.},
  author={H X Liu and Pablo Rodolfo Brumovsky and Ralf Schmidt and William Wesley Brown and Kemal Payza and Lejla Hodzic and Charles Pou and Claude Godbout and Tomas G M H{\"o}kfelt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 17},
  pages={9960-4}
}
Galanin is a 29-aa neuropeptide with a complex role in pain processing. Several galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. Here, we describe a generation of a specific galanin R2 (GalR2) agonist, AR-M1896, and its application in studies of a rat neuropathic pain model (Bennett). The results show that in normal rats mechanical and cold allodynia of the hindpaw are induced after intrathecal infusion of low-dose galanin (25 ng per… CONTINUE READING
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