Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug.

@article{Sinkkonen2003ReceptorSP,
  title={Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug.},
  author={Saku T. Sinkkonen and Salla Mansikkam{\"a}ki and Tommi M{\"o}ykkynen and Hartmut L{\"u}ddens and Mikko Uusi-Oukari and Esa R Korpi},
  journal={Molecular pharmacology},
  year={2003},
  volume={64 3},
  pages={753-63}
}
In addition to blocking cyclooxygenases, members of the fenamate group of nonsteroidal anti-inflammatory drugs have been proposed to affect brain GABAA receptors. Using quantitative autoradiography with GABAA receptor-associated ionophore ligand [35S]t-butylbicyclophosphorothionate (TBPS) on rat brain sections, one of the fenamates, niflumate, at micromolar concentration was found to potentiate GABA actions in most brain areas, whereas being in the cerebellar granule cell layer an efficient… CONTINUE READING
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