Receptor specificity of H5 influenza virus escape mutants.

  title={Receptor specificity of H5 influenza virus escape mutants.},
  author={Natalia A Ilyushina and Irina A. Rudneva and Alexandra S. Gambaryan and Alexander B. Tuzikov and Nicolai V. Bovin},
  journal={Virus research},
  volume={100 2},
The binding of viruses to synthetic polyacrylamide (PAA)-based sialylglycoconjugates was used to characterize the receptor specificities of antibody escape mutants of the influenza virus A/Mallard/Pennsylvania/10218/84 (H5N2). The sialylglycoconjugates that were used carried identical terminal Neu5Acalpha2-3Gal moieties but differed in the structure of the next saccharide residue(s). Our data show that mutations in the vicinity of the haemagglutinin (HA) receptor-binding site (RBS) effect the… CONTINUE READING