Receptor-specific targeting mediated by the coexpression of a targeted murine leukemia virus envelope protein and a binding-defective influenza hemagglutinin protein.

@article{Lin2001ReceptorspecificTM,
  title={Receptor-specific targeting mediated by the coexpression of a targeted murine leukemia virus envelope protein and a binding-defective influenza hemagglutinin protein.},
  author={Amy H.-M. Lin and Noriyuki Kasahara and Wenman Wu and Renata Stripecke and Cyril Empig and W. French Anderson and Paula M. Cannon},
  journal={Human gene therapy},
  year={2001},
  volume={12 4},
  pages={323-32}
}
The entry of retroviral vectors into cells requires two events: binding to a cell surface receptor and the subsequent fusion of viral and cellular membranes. The host range of a vector is therefore determined largely by the receptor specificity of the fusion protein contained in the outer viral envelope. Previous attempts to generate targeted retroviral vectors have included the addition of targeting ligands to the murine leukemia virus envelope protein (MuLV Env). Although such proteins… CONTINUE READING

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