Receptor-specific influence of endothelin-1 in the erectile response of the rat.

@article{Dai2000ReceptorspecificIO,
  title={Receptor-specific influence of endothelin-1 in the erectile response of the rat.},
  author={Yutian Dai and David M Pollock and Richard L. Lewis and Christopher J Wingard and Vivienne S. Stopper and Thomas Martin. Mills},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2000},
  volume={279 1},
  pages={
          R25-30
        }
}
Specific receptor antagonists were used to examine the role of endothelin-1 (ET-1) in the erectile response of the rat. In these studies, intact rats were cannulated to permit the continuous recording of mean arterial pressure (MAP) and intracavernosal pressure (CCP). Erection was induced by electrical stimulation of the autonomic ganglion, which regulates blood flow to the penis. The animals were subjected to intracavernosal injection with vehicle only (Cont) or with an antagonist to the… CONTINUE READING

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