Receptor selectivity of icv morphine in the rat cold water tail-flick test.

@article{Adams1994ReceptorSO,
  title={Receptor selectivity of icv morphine in the rat cold water tail-flick test.},
  author={Jill U. Adams and Ellen B. Geller and Martin W. Adler},
  journal={Drug and alcohol dependence},
  year={1994},
  volume={35 3},
  pages={
          197-202
        }
}
The cold water tail-flick test in the rat is somewhat unique in that it is sensitive to the analgesic effects of delta- and kappa- in addition to mu-opioid agonists. The present study was designed to test whether a component of morphine-induced analgesia in this test might be mediated by delta- or kappa-opioid receptors. Morphine was administered icv in combination with the non-selective opioid antagonist naloxone (NLX), as well as the mu-, delta- and kappa-selective antagonists, D-Phe-Cys-Tyr… CONTINUE READING