Receptor-selective changes in mu-, delta- and kappa-opioid receptors after chronic naltrexone treatment in mice.

Chronic treatment with the opioid antagonist naltrexone induces functional supersensitivity to opioid agonists, which may be explained by receptor up-regulation induced by opioid receptor blockade. In the present study, the levels of opioid receptor subtypes through the brain of mice were determined after chronic naltrexone treatment using quantitative in… CONTINUE READING