Receptor seeks ligand: On the way to cloning the molecular receptors for sweet and bitter taste

@article{Lindemann1999ReceptorSL,
  title={Receptor seeks ligand: On the way to cloning the molecular receptors for sweet and bitter taste},
  author={Bernd Lindemann},
  journal={Nature Medicine},
  year={1999},
  volume={5},
  pages={381-382}
}
  • B. Lindemann
  • Published 1 April 1999
  • Biology, Medicine
  • Nature Medicine
The cloning of two new taste receptors represents a scrumptious advance for this field of research, but determining their flavor still leaves one feeling slightly hungry 
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Using reverse transcription-polymerase chain reaction (RT-PCR) and degenerate oligonucleotide primers, we amplified novel members of two different subfamily of G-protein coupled receptor (GCR)
Two types of sugar-binding protein in the labellum of the fly. Putative taste receptor molecules for sweetness
TLDR
These proteins showed consistent sugar-binding specificities and affinities with the two types of receptor sites for sweetness, respectively, and are likely to act as the taste receptor molecules for sweetness in the fly.
The Taste of Monosodium Glutamate: Membrane Receptors in Taste Buds
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It is concluded that mGluR4 may be a chemosensory receptor responsible, in part, for the taste of MSG.
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Taste transduction typically utilizes two or more pathways in parallel, and to identify these pathways, to understand how they are controlled and why they evolved to this complexity are major goals of present research.
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TLDR
Gustducin is a principal mediator of both bitter and sweet signal transduction, and its role in taste transduction is investigated by generating and characterizing mice deficient in the gustducin α-subunit.
The Arginine Taste Receptor: Physiology, Biochemistry, and Immunohistochemistry a
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To purify the receptor, CHAPS solubilized partial membrane preparation from barbel epithelium to RCA I lectin affinity chromatography showed a high molecular weight peak (>700 kDa) which was recognized by the antibodies and may be aggregates of the arginine taste receptor.
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