Receptor reserve analysis of the human CCR3 receptor in eosinophils and CCR3-transfected cells.

@article{Umland2000ReceptorRA,
  title={Receptor reserve analysis of the human CCR3 receptor in eosinophils and CCR3-transfected cells.},
  author={Shelby P. Umland and Yuntao Wan and J Shortall and Himanshu Shah and James P Jakway and C G Garlisi and Fang Tian and Robert W. Egan and M. Motasim Billah},
  journal={Journal of leukocyte biology},
  year={2000},
  volume={67 3},
  pages={441-7}
}
A novel pharmacological study of CCR3 receptor reserve in a CCR3-transfected cell (CREM3) and human eosinophils was done; functional responses measured were increases in intracellular calcium and chemotaxis. Eotaxin, eotaxin-2, monocyte chemoattractant protein-4 (MCP-4), RANTES, and MCP-3 induced similar maximal eosinophil chemotaxis, whereas MCP-3 and RANTES induced submaximal calcium responses in eosinophils compared to eotaxin, MCP-4, and eotaxin-2. This suggested a receptor reserve in the… CONTINUE READING

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