Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells.

@article{Jobin2003ReceptorregulatedDI,
  title={Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells.},
  author={Charles M. Jobin and H. -S. V Chen and Alison J. Lin and Patrick W. Yacono and Junsuke Igarashi and Thomas M. Michel and David Eric Golan},
  journal={Biochemistry},
  year={2003},
  volume={42 40},
  pages={
          11716-25
        }
}
The endothelial isoform of nitric oxide synthase (eNOS), a key regulator of vascular tone, is activated in endothelial cells by diverse Ca(2+)-mobilizing agonists, including vascular endothelial growth factor (VEGF). Although the activation state of eNOS and the subcellular localization of the enzyme are both highly regulated, the relationship between enzyme activity and subcellular targeting remains obscure. We aim here to elucidate this relationship by direct dynamic imaging analysis of Ca(2… CONTINUE READING
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