Receptor protein tyrosine phosphatase sigma inhibits axonal regeneration and the rate of axon extension

@article{Thompson2003ReceptorPT,
  title={Receptor protein tyrosine phosphatase sigma inhibits axonal regeneration and the rate of axon extension},
  author={Karen MacDonald Thompson and N Uetani and Colleen Manitt and Mounib Elchebly and Timothy E Kennedy},
  journal={Molecular and Cellular Neuroscience},
  year={2003},
  volume={23},
  pages={681-692}
}
Transgenic mice lacking receptor protein tyrosine phophatase-sigma (RPTPsigma), a type IIa receptor protein tyrosine phosphatase, exhibit severe neural developmental deficits. Continued expression of RPTPsigma in the adult suggests that it plays a functional role in the mature nervous system. To determine if RPTPsigma might influence axonal regeneration, the time course of regeneration following facial nerve crush in wild-type and RPTPsigma (-/-) mice was compared. Mice lacking RPTPsigma… CONTINUE READING
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