Receptor protein tyrosine phosphatase α is essential for hippocampal neuronal migration and long‐term potentiation

@article{Petrone2003ReceptorPT,
  title={Receptor protein tyrosine phosphatase $\alpha$ is essential for hippocampal neuronal migration and long‐term potentiation},
  author={A. Petrone and F. Battaglia and Cheng Wang and Adina Dusa and J. Su and D. Zagzag and R. Bianchi and P. Casaccia‐Bonnefil and O. Arancio and J. Sap},
  journal={The EMBO Journal},
  year={2003},
  volume={22}
}
Despite clear indications of their importance in lower organisms, the contributions of protein tyrosine phosphatases (PTPs) to development or function of the mammalian nervous system have been poorly explored. In vitro studies have indicated that receptor protein tyrosine phosphatase α (RPTPα) regulates SRC family kinases, potassium channels and NMDA receptors. Here, we report that absence of RPTPα compromises correct positioning of pyramidal neurons during development of mouse hippocampus… Expand
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TLDR
The normal development of neurons and glia in RPTPβ-deficient mice demonstrates that RPTP β function is not necessary for these processes in vivo or that loss ofRPTPβ can be compensated for by other PTPs expressed in the nervous system. Expand
Protein tyrosine phosphatase σ‐deficient mice show aberrant cytoarchitecture and structural abnormalities in the central nervous system
TLDR
The data suggest that PTPσ is likely involved in neurogenesis, axonal growth, and axonal pathfinding in the maturation of the mammalian CNS, suggesting a delay in neurological development related to the knockout of the Ptprs gene. Expand
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TLDR
Results suggest that tyrosine phosphorylation-dependent signalling pathways regulated by PTP-σ influence the proliferation and/or adhesiveness of various cell types in the developing hypothalamo-pituitary axis. Expand
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It is found that application of the PTPα catalytic domains (D1 + D2) into neurones enhances NMDA receptor‐mediated synaptic responses and is a novel up‐regulator of synaptic strength in the CNS. Expand
Receptor protein tyrosine phosphatase alpha activates pp60c‐src and is involved in neuronal differentiation.
TLDR
The results demonstrate that RPTP alpha is involved in neuronal differentiation and imply a role for pp60c‐src in the differentiation process, and demonstrate that protein tyrosine phosphatases (PTPases) can play an important role in cell differentiation. Expand
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TLDR
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TLDR
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TLDR
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TLDR
It is demonstrated that RPTP alpha is differentially expressed during mouse embryogenesis in a spatio-temporal manner, and the expression pattern of RPTPalpha suggests thatRPTP alpha may play a role in neural crest cell differentiation in vivo. Expand
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