Receptor protein tyrosine kinase DDR is up‐regulated by p53 protein

  title={Receptor protein tyrosine kinase DDR is up‐regulated by p53 protein},
  author={Shirou Sakuma and Hideyuki Saya and Mitsuhiro Tada and M Nakao and Toshiyoshi Fujiwara and Jack A. Roth and Yutaka Sawamura and Yumiko Shinohe and Hiroshi Abe},
  journal={FEBS Letters},
p53 induction and activation of DDR1 kinase counteract p53‐mediated apoptosis and influence p53 regulation through a positive feedback loop
DDR1, discoidin domain receptor 1, belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. We showed that DDR1 is
Transcriptional control of human p53-regulated genes
The most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation is presented.
Differential Recognition of Response Elements Determines Target Gene Specificity forp53 and p63
The results indicate that p63 can regulate expression of specific target genes such as those involved in skin, limb, and craniofacial development by preferentially activating distinct p63-specific response elements.
Identification of Receptor Tyrosine Kinase, Discoidin Domain Receptor 1 (DDR1), as a Potential Biomarker for Serous Ovarian Cancer
The results suggest that the expression of DDR1 may serve as both a potential biomarker and a molecular target for advanced ovarian cancer.
Identification of two novel, kinase‐deficient variants of discoidin domain receptor 1: differential expression in human colon cancer cell lines
Exogenous overexpression of DDR1d in transient transfection assays supported a nondominant negative mechanism of signal modulation, and stimulation with collagen induced full‐length receptor phosphorylation suggested a lack of dominant‐negative inhibition by DDR1D.
Human Cancer Biology InhibitionofCollagenReceptorDiscoidinDomainReceptor-1 ( DDR 1 ) Reduces Cell Survival , Homing , and Colonization in Lung Cancer Bone Metastasis
The role of the collagen-binding receptor discoidin domain receptor-1 (DDR1) in the initiation and development of bone metastasis is investigated in lung cancer specimens and phosphorylation status in a panel of human lung cancer cell lines is examined.
Discoidin domain receptor tyrosine kinases: new players in cancer progression
This review summarizes and discusses the current knowledge on DDR expression and function in cancer, and hopes that this effort will encourage more research into these poorly understood but unique RTKs, which have the potential of becoming novel therapeutic targets in cancer.
An investigation of the aberrant expression and activation of receptor tyrosine kinases in hodgkin’s lymphoma
It is shown that HL cells are sensitive to the RTK inhibitor, dasatinib, and consistent with the aberrant activation of multiple RTKs in HL cells, these cells were also sensitive to lestaurtinib and dovitinib, two next generation multiple-target RTK inhibitors.
Discoidin domain receptor 1 isoform‐a (DDRla) promotes migration of leukocytes in three‐dimensional collagen lattices
It is proposed that the interaction of DDR1a with collagen of the ECM results in a requisite intracellular signaling that enables leukocytes to migrate in a tissue microenvironment and participate in host defense.
Contribution of p53 to metastasis.
Understanding the mechanisms by which p53 loss and mutation promote tumor metastasis is crucial to understanding the biology of tumor progression and how to appropriately apply targeted therapies.


Radiation induction of the receptor tyrosine kinase gene Ptk-3 in normal rat astrocytes.
Radiation-induced gene expression was examined in rat astrocyte cultures using differential display of mRNA via reverse transcriptase-polymerase chain reaction and indicated the presence of at least two Ptk-3 mRNA transcripts, which are probably the result of an alternative splicing mechanism.
Expression patterns of the novel receptor-like tyrosine kinase, DDR, in human breast tumours.
The expression of the discoidin domain receptor is demonstrated in human primary breast tumour samples, metastasis-containing lymph nodes and a number of normal tissues by Northern blotting and in situ hybridisation.
Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases (*)
Evidence is provided that phosphorylation of serine 378 within the carboxyl-terminal negative regulatory domain of the human p53 protein by protein kinase C correlates with loss of PAb421 reactivity and a concomitant activation of sequence-specific DNA binding.
Definition of a consensus binding site for p53
Recent experiments have suggested that p53 action may be mediated through its inter action with DNA. We have now identified 18 human genomic clones that bind to p53 in vitro. Precise mapping of the
Inactivation of p53 gene in human and murine osteosarcoma cells.
The results suggest that the inactivation of p53 may be an important step in the development of osteosarcomas, and that a rearrangement affecting the first intron is common in osteosARcomas.