Receptor pharmacological models for inner ear therapies with emphasis on glutamate receptors: a survey.

@article{Ehrenberger1995ReceptorPM,
  title={Receptor pharmacological models for inner ear therapies with emphasis on glutamate receptors: a survey.},
  author={Klaus Ehrenberger and Dominik Felix},
  journal={Acta oto-laryngologica},
  year={1995},
  volume={115 2},
  pages={236-40}
}
With the aid of microiontophoretic techniques we evaluated the action of different postsynaptic glutamate receptor subtypes that mediate neurotransmission between the inner hair cell and the afferent neuron. The sensory input is modulated by axodendritic efferents. In the central nervous system, excessive activation of glutamate receptors is thought to be responsible for a wide variety of neurotoxic actions, and calcium is involved in the etiology of glutamate-induced cell damage. Glutamatergic… CONTINUE READING