Receptor-mediated suppression of potassium currents requires colocalization within lipid rafts.

  title={Receptor-mediated suppression of potassium currents requires colocalization within lipid rafts.},
  author={Susan Oldfield and Jane Hancock and Angharad Mason and Sally A Hobson and David Wynick and Eamonn Kelly and Andrew D Randall and Neil V. Marrion},
  journal={Molecular pharmacology},
  volume={76 6},
Expression of KCNQ2/3 (Kv7.2 and -7.3) heteromers underlies the neuronal M current, a current that is suppressed by activation of a variety of receptors that couple to the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Expression of Kv7.2/7.3 channels in human embryonic kidney (HEK) 293 cells produced a noninactivating potassium current characteristic of M current. Muscarinic receptors endogenous to HEK293 cells were identified as being M3 by pharmacology and Western blotting, producing a… CONTINUE READING
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