Receptor-mediated stimulatory effect of oligochitosan in macrophages.

  title={Receptor-mediated stimulatory effect of oligochitosan in macrophages.},
  author={Jie Feng and Luhang Zhao and Qiqi Yu},
  journal={Biochemical and biophysical research communications},
  volume={317 2},
Oligochitosan, which has greater than 3 but less than 10 saccharide (N-acetylglucosamine or glucosamine) residues, is obtained by either chemical or enzymatic hydrolysis of chitosan. In this work, we demonstrated that oligochitosan had an in vitro stimulatory effect on the release of tumor necrosis factor-alpha and interleukin-1 beta in macrophages. Moreover, we observed that oligochitosan could be uptaken by macrophages through confocal laser microscopy. Scatchard analysis of internalization… CONTINUE READING


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