Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival.

  title={Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival.},
  author={Norikiyo G Ueno and Mary Edythe Wilson},
  journal={Trends in parasitology},
  volume={28 8},
The extracellular promastigote stage of Leishmania spp. is transmitted to mammals by a sand fly vector. Leishmania promastigotes ligate host macrophage receptors, triggering phagocytosis and subsequent internalization, a crucial step for survival. Parasites transform intracellularly to the amastigote stage. Many studies document different receptors detecting promastigotes and amastigotes, but the relative importance of each interaction is ill-defined. Recent studies suggest that the macrophage… CONTINUE READING

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