Receptor-mediated oligodeoxynucleotides delivery by estradiol and folic acid polylysine conjugates.

  title={Receptor-mediated oligodeoxynucleotides delivery by estradiol and folic acid polylysine conjugates.},
  author={Gennaro Citro and Patrizia Ginobbi and Cezary Szczylik},
  volume={11 Suppl 1},
The lack of efficient and specific delivery to target cells still limits the potential application of antisense oligodeoxynucleotides as therapeutic agents in cancer disease. We have covalently linked a polylysine chain (10,000-20,000 mw) to compounds as folic acid, retinoic acid, transferrin, insulin and estradiol, to deliver c-myb antisense oligonucleotide into tumor cells. Using these complexes as carriers for the oligodeoxynucleotides can be achieved an increase in their uptake into target… CONTINUE READING

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