Receptor-mediated hepatocarcinogenesis: role of hepatocyte proliferation and apoptosis.

@article{Oliver2002ReceptormediatedHR,
  title={Receptor-mediated hepatocarcinogenesis: role of hepatocyte proliferation and apoptosis.},
  author={Jason D Oliver and Ruth A Roberts},
  journal={Pharmacology & toxicology},
  year={2002},
  volume={91 1},
  pages={1-7}
}
The rodent liver is a target organ for the action of several non-genotoxic carcinogens. These include dioxins, polychlorinated biphenyls, phenobarbital, peroxisome proliferators and organochlorine pesticides. These chemicals disrupt the homeostasis of the liver by perturbing hepatocyte cell death and proliferation, causing hyperplasia leading to tumour formation. Significant progress has been made towards elucidating the mechanisms of action of these toxicants since the discovery of receptors… CONTINUE READING