Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

@article{HARDING1983ReceptormediatedEO,
  title={Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes},
  author={CHAS. HARDING and John M Heuser and Philip Stahl},
  journal={The Journal of Cell Biology},
  year={1983},
  volume={97},
  pages={329 - 339}
}
At 4 degrees C transferrin bound to receptors on the reticulocyte plasma membrane, and at 37 degrees C receptor-mediated endocytosis of transferrin occurred. Uptake at 37 degrees C exceeded binding at 4 degrees C by 2.5-fold and saturated after 20-30 min. During uptake at 37 degrees C, bound transferrin was internalized into a trypsin-resistant space. Trypsinization at 4 degrees C destroyed surface receptors, but with subsequent incubation at 37 degrees C, surface receptors rapidly appeared… CONTINUE READING
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